So the cancer cells can escape from the body's immune defenses.
The scientific basis of using the immunotherapy by DC is to remove this protective protein layer surrounding the cancer cell, such hhat the immune system can recoginize and destroy thesecells effectivelyMoreover, the DC therapy enables the body to create immunological memory against these cancer cells, and prevent cancer recurrence.
An effective way to combat tumor cells remaining after radical treatment and creating a threat of relapse of the disease is to activate the patient's own immune system. Modern methods of personalized cell-mediated immunotherapy are using the patient’s own immune cells programmed to attack and destroy cancer cells. The main task of activating the antitumor immunity of a patient is performed by his own dendritic cells (DC), which are the specialized and most powerful antigen-presenting cells, and with the help of which one can initiate a directed immune response against the tumor. Immunotherapy is indicated for patients with chemoresistant solid tumors (cancer of the stomach, pancreas, breast, bladder, lungs, etc.) Usually - after a radical surgery and standard postoperative treatment (chemoradiotherapy).
SAFETY & BENEFITS
The course introduction of an antitumor vaccine allows stabilization of the oncological process and the timing of subsequent lines of chemotherapy, and also often increases the disease-free period, and, in general, life expectancy. The clinical effect of one course of immunotherapy (5 doses) is manifested by stabilization of the tumor process (in 40 - 50% of cases), sometimes with partial or full regression (5 - 15%), and can last, on average, from 3 months to a year or more . The maximum clinical effect of DC can be expected if it is carried out continuously in the adjuvant mode after removal of the primary lesion (after surgery) in order to prevent tumor recurrence and to destroy invisible micrometastases. Clinical studies on the use of DCs for the treatment of malignant neoplasms have been conducted in leading medical centers in the world for more than 20 years, and the results of most of them are encouraging - the safety of using DCs, activation of the immune system, and significant clinical effect have been proved. There is a likelihood of low efficiency of DCs when using standardized synthetic tumor-associated antigens for their production, the expression of which by the tumor is not confirmed by immunohistochemical data. That is why an immunohistochemical analysis is highly desirable. It is proved that the use of autologous DCs is completely safe, does not cause allergic, toxic reactions, does not suppress immunity and does not stimulate tumor growth. Direct administration of the vaccine can be accompanied by a short-term (1-2 days) increase in body temperature up to 38 ° C, redness and swelling of the injection site, which do not require medical attention and pass on their own
To develop treatment tactics and determine the vaccination schedule, a specialist oncologist of the Department of Regenerative Medicine and Cell Therapy carries out all the diagnosis procedures andcompulsory examinations.
The biomaterial for obtaining CELL PRODUCT based on Dendritic Cells is peripheral venous blood (50-100 ml). The biomaterial extraction is a routine medical manipulation. From a single volume of blood, 1 dose of the vaccine is produced. The number of dendritic cells is determined by the number of native monocytes in the patient’s biomaterial - with their low content in the blood, the number of DCs will also be low.
Monocytes isolated from blood are “loaded” with tumor antigens in the laboratory, which allows to obtain mature dendritic cells that can activate the immune response. Individual antigenic tumor antigens (tumor lysates), as well as synthetic standardized tumor-associated antigens, are used as the antigenic material for creating the vaccine.
An anti-tumor vaccine based on DC is administered by a course of 5 therapeutic doses. The administration of the vaccine (1-2 ml) is a routine medical manipulation, performed subcutaneously in the shoulder or forearm, is performed on an outpatient basis in a treatment room. Immediately after vaccination, the patient is observed for 1 to 2 hours in a ward.
1- It removes the protective layer that the cancer cell secretes around itself so that it is not subject to destruction by the immune system.
2- In conjunction with chemotherapy or any other traditional treatments, the efficiency of these treatments increases by 200 to 300 percent as a result of removing the protective layer around the cancer cell
3- It creates antibodies in the body for the same type of cancer, which prevents the cancer from spreading again after the success of treatment, especially in some cases. After surgical removal
4- It has no any serious complications, so it can be used in advanced cases
5- It achieves clear results for cases of incurable cancers, resistant to chemotherapy, and metastatic and terminal cancers
6- The treatment is extracted from the same immune cells from the patient’s body to treat the same type of cancer specified in the patient’s body It is not a chemical treatment, which confirms its use safety without the occurrence of complications associated with chemical treatments
Adult mesenchymal stem cells (MSCs) are being used by our medical professionals in the fields of regenerative medicine and tissue engineering, to artificially reconstruct human tissue which has been previously damaged. Mesenchymal stem cells have the capacity to become any type of fully developed cell, which can contribute to replacing cartilage tissues or internal organs. With so many treatment options out there, you may be wondering what benefits choosing stem cell therapy provides. Overall, because stem cell therapy utilizes biologic material harvested directly from the patient’s body, the general benefits include minimal risk, minimal recovery time and minimal worry.
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective membrane (myelin), which covers the nerve fibers and causes communication problems between your brain and the rest of the body.
is the most common form of motor neuron disease, which is a neurodegenerative disease that affects motor neurons in the brain and spinal cord. Nowadays, no ways have been developed to defeat the disease itself. Therefore, the existing treatment solves two problems: prolonging life and improving its quality by combating symptoms. Cell therapy is one of the most effective methods for solving these problems.
We use most advanced technology of neuroinduced stem cells to treat brain damaged cells due to stroke, injuries as well as toxic effects like severe acidosis and ethanol toxicity with great results never achieved before.
is a degenerative pathology that affects bone joints. The symptom that primarily characterizes the disease is pain, which may be accompanied by difficulties in movement and deformation. The most affected moving joints are the hips, knees and shoulders. Read More... EPILEPSY Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness.
In the tissues of the oral cavity, disorders can occur that cause a lack of blood supply, as a result of which the state of the gums, palate - the entire oral cavity changes. Such a disease is called periodontitis.
Cellular therapy of age-related skin changes is based on the use of the patient’s own fibroblasts of the patient’s skin, isolated and propagated in laboratory conditions. The use of cultured autologous dermal fibroblasts (hereinafter referred to as DF) allows to replenish the population of these cells lost with age by introducing young and functionally active fibroblasts into the skin. Fibroblasts are the main cellular component of the skin, providing its homeostasis and morphofunctional organization. They perform a number of diverse and complex functions in the skin: they control the composition and structure of the extracellular matrix of the dermis (collagen, elastin, proteoglycans and structural glycoproteins), and their function includes not only the production of these substances, but also their catabolism. Thus, fibroblasts are a key link in skin biology - they not only control the homeostasis of the extracellular matrix of the dermis, providing for its remodeling and renewal, but also maintain the physiological state of all layers of the skin.
HOW IT WORKS
The use of cultured autologous dermal fibroblasts makes up for the lost population of these cells with age.
After transplantation, cultured DFs are fully integrated into the dermis
The biosynthetic activity of DF is maintained for at least 12 months as a result, there is a remodeling of the microstructure of the dermis, an increase in the content of collagen fibers in it.
The hydration of the skin increases, its density and thickness increases as well.
Active fibroblasts being introduced into the skin , start the natural processes of the dermis restoration The number of dermal cells in the transplantation zone increases, as well as the synthesis of own collagen, microcirculation is restored, metabolic processes and blood circulation are stimulated.
The high efficiency of the method is due to the ability of implanted living own cells for a long time (8-9 months) to produce biologically active substances characteristic of young skin: its strength and elasticity increase, and the lifting effect occurs. The result of implantation of living cells: wrinkles, scars, striae disappear. The dermis is completely renewed, a healthy skin color is restored, its turgor rises, the skin becomes velvety, dryness and peeling disappear. The effect of the procedure begins to manifest itself after 6 - 8 hours after the session and increases over time. After 8 to 9 months after the course of treatment, a persistent positive result is observed. The clinical effect has a growing character throughout the year and persists for at least 3 years