World leader of DENDRITIC cell cancer immunotherapy

CANCER

IMMUNOTHERAPY 

INTRODUCTION:
Scientists have investigated why
some cancers respond to conventional treatment while others do not.
They found that the reason lies in the presence of a protein called
(ENPP1) found on the outside surface of some cancer cells, it tricks the immune system by looking like normal cells in the patient's body.

So the cancer cells can escape from the body's immune defenses.

The scientific basis of using the  immunotherapy by DC is to remove this protective protein layer surrounding the cancer cell, such hhat the immune system can recoginize and destroy  thesecells effectivelyMoreover, the DC therapy enables the body to create immunological memory against these cancer cells, and prevent cancer recurrence.

Nature and indications for Dendritic cell immunotherapy

An effective way to combat tumor cells remaining after radical treatment and creating a threat of relapse of the disease is to activate the patient's own immune system. Modern methods of personalized cell-mediated immunotherapy are using the patient’s own immune cells programmed to attack and destroy cancer cells. The main task of activating the antitumor immunity of a patient is performed by his own dendritic cells (DC), which are the specialized and most powerful antigen-presenting cells, and with the help of which one can initiate a directed immune response against the tumor. Immunotherapy is indicated for patients with chemoresistant solid tumors (cancer of the stomach, pancreas, breast, bladder, lungs, etc.) Usually - after a radical surgery and standard postoperative treatment (chemoradiotherapy).

SAFETY & BENEFITS

The course introduction of an antitumor vaccine allows stabilization of the oncological process and the timing of subsequent lines of chemotherapy, and also often increases the disease-free period, and, in general, life expectancy. The clinical effect of one course of immunotherapy (5 doses) is manifested by stabilization of the tumor process (in 40 - 50% of cases), sometimes with partial or full regression (5 - 15%), and can last, on average, from 3 months to a year or more . The maximum clinical effect of DC can be expected if it is carried out continuously in the adjuvant mode after removal of the primary lesion (after surgery) in order to prevent tumor recurrence and to destroy invisible micrometastases. Clinical studies on the use of DCs for the treatment of malignant neoplasms have been conducted in leading medical centers in the world for more than 20 years, and the results of most of them are encouraging - the safety of using DCs, activation of the immune system, and significant clinical effect have been proved. There is a likelihood of low efficiency of DCs when using standardized synthetic tumor-associated antigens for their production, the expression of which by the tumor is not confirmed by immunohistochemical data. That is why an immunohistochemical analysis is highly desirable. It is proved that the use of autologous DCs is completely safe, does not cause allergic, toxic reactions, does not suppress immunity and does not stimulate tumor growth. Direct administration of the vaccine can be accompanied by a short-term (1-2 days) increase in body temperature up to 38 ° C, redness and swelling of the injection site, which do not require medical attention and pass on their own


DCV2

TREATMENT REGIMEN

Stage 1 - COMPREHENSIVE                               CHECK-UP 

To develop treatment tactics and determine the vaccination schedule, a specialist oncologist of the Department of Regenerative Medicine and Cell Therapy carries out all the diagnosis procedures andcompulsory examinations.

Stage 2 - BIOMATERIAL                              SAMPLING. 

The biomaterial for obtaining CELL PRODUCT based on Dendritic Cells is peripheral venous blood (50-100 ml). The biomaterial extraction is a routine medical manipulation. From a single volume of blood, 1 dose of the vaccine is produced. The number of dendritic cells is determined by the number of native monocytes in the patient’s biomaterial - with their low content in the blood, the number of DCs will also be low.

Stage 3 - BIOMATERIAL                            PRODUCTION

Monocytes isolated from blood are “loaded” with tumor antigens in the laboratory, which allows to obtain mature dendritic cells that can activate the immune response. Individual antigenic tumor antigens (tumor lysates), as well as synthetic standardized tumor-associated antigens, are used as the antigenic material for creating the vaccine.

Stage 4 - BIOMATERIAL                      TRANSPLANTATION

An anti-tumor vaccine based on DC is administered by a course of 5 therapeutic doses. The administration of the vaccine (1-2 ml) is a routine medical manipulation, performed subcutaneously in the shoulder or forearm, is performed on an outpatient basis in a treatment room. Immediately after vaccination, the patient is observed for 1 to 2 hours in a ward.

Advantages of dendritic cell cancer immunotherapy.


1- It removes the protective layer that the cancer cell secretes around itself so that it is not subject to destruction by the immune system.


2- In conjunction with chemotherapy or any other traditional treatments, the efficiency of these treatments increases by 200 to 300 percent as a result of removing the protective layer around the cancer cell


3- It creates antibodies in the body for the same type of cancer, which prevents the cancer from spreading again after the success of treatment, especially in some cases. After surgical removal


4- It has no any serious complications, so it can be used in advanced cases


5- It achieves clear results for cases of incurable cancers, resistant to chemotherapy, and metastatic and terminal cancers


 6- The treatment is extracted from the same immune cells from the patient’s body to treat the same type of cancer specified in the patient’s body It is not a chemical treatment, which confirms its use safety without the occurrence of complications associated with chemical treatments


KIDNEY TRANSPLANTATION 

Kidney transplantation in Belarus is masterfully performed by experienced surgeons with European qualifications. It is worth noting that more than 2,000 kidneys have been successfully transplanted, which is a very good result and far exceeds the same figures in the neighboring countries.
The Republic of Belarus is currently in the first place in the CIS and the eighth in the world in terms of the number of kidney transplants per 1 million population.
From year to year clinics of Belarus perform hundreds of surgical interventions for kidney transplants. And this is why kidney transplantation in Belarus is so in demand among medical tourists from all over the world:
In Belarus, transplantation from unrelated donors is legally permitted (unlike other countries) - this is the main advantage;
Belarusian doctors managed to overcome the main difficulties of this operation - the technological complexity of surgical intervention, kidney rejection in the postoperative period;
Based on statistical data, 92% of operations have beneficial effects, or rather patients recover and return to their normal lifestyle;
Medical specialists of the country have many years of experience;
Clinics use innovative methods and constantly improve staff skills;
All Belarusian clinics are equipped with the latest equipment;
Carefully selected each donor so that the organ maximally suits the patient.
The survival rate after kidney transplantation is 85 - 90%. This is a very high rate and is on par with clinics in the European Union.
A kidney transplant in Belarus involves three phases:
The kidney is taken from the donor (if it is alive relative of the patient, then the organ is taken laparoscopically, which means there is less risk of injury, and recovery of the donor itself will take much less time);
The organ is being prepared for transplantation;
The transplantation surgery itself (general anesthesia is used, the time of surgery is from 3 to 8 hours).
As a rule, the patient’s own kidneys are not removed. And for the safety of the transplant, it is mandatory to take drugs aimed at artificially suppressing immunity.

After transplantation, the diet is systematically changed until the newly appeared kidney begins to work in full.

When the clinic discharges the patient, he is instructed to observe safety and maintain vital functions.
OVER 20 YEARS OF EXPERIENCE 
STEM CELL THERAPY USING BIOLOGICAL CULTURING METHOD

STEM CELL THERAPY

(CELL ENGINEERING)


Precision Medical

carries out 18 clinically proven protocols for the treatment of various diseases and are constantly working on the creation of new techniques most important is the neuroinduced stem cells that can effectively regenerate and sctivate damaged brain cells.

The average number of stem cells required for successful treatment is 2 million cells per 1 kg of patient body weight. To get this number of active living cells, our team of cell engineers conducts an explantation (cultivation) procedure for up to 30 days in a certified laboratory.

STEM CELL THERAPY USING BIOLOGICAL CULTUVATION OF AUTOLOGOUS  MESENCHYMAL

STEM CELLS 

Adult mesenchymal stem cells (MSCs) are being used by our medical professionals in the fields of regenerative medicine and tissue engineering, to artificially reconstruct human tissue which has been previously damaged. Mesenchymal stem cells have the capacity to become any type of fully developed cell, which can contribute to replacing cartilage tissues or internal organs. With so many treatment options out there, you may be wondering what benefits choosing stem cell therapy provides. Overall, because stem cell therapy utilizes biologic material harvested directly from the patient’s body, the general benefits include minimal risk, minimal recovery time and minimal worry.

DISEASES TREATED BY STEM CELLS

 AT OUR CENTER


MULTIPLE SCLEROSIS

Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective membrane (myelin), which covers the nerve fibers and causes communication problems between your brain and the rest of the body. 


Amyotrophic lateral sclerosis

is the most common form of motor neuron disease, which is a neurodegenerative disease that affects motor neurons in the brain and spinal cord. Nowadays, no ways have been developed to defeat the disease itself. Therefore, the existing treatment solves two problems: prolonging life and improving its quality by combating symptoms. Cell therapy is one of the most effective methods for solving these problems. 

BRAIN CELL

DAMAGE


We use most advanced technology of neuroinduced stem cells to treat brain damaged cells due to stroke, injuries as well as toxic effects like severe acidosis and ethanol toxicity with great results never achieved before.



OSTEO ARTHRITIS Arthrosis


 is a degenerative pathology that affects bone joints. The symptom that primarily characterizes the disease is pain, which may be accompanied by difficulties in movement and deformation. The most affected moving joints are the hips, knees and shoulders. Read More... EPILEPSY Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness. 


GUMS RECESSION TREATMENT

  In the tissues of the oral cavity, disorders can occur that cause a lack of blood supply, as a result of which the state of the gums, palate - the entire oral cavity changes. Such a disease is called periodontitis. 

ANTI-AGING STEM CELL TREATMENT
DERMAL BIO RRVITALIZATION

CELLULAR REJUVENATION

Cellular therapy of age-related skin changes is based on the use of the patient’s own fibroblasts of the patient’s skin, isolated and propagated in laboratory conditions. The use of cultured autologous dermal fibroblasts (hereinafter referred to as DF) allows to replenish the population of these cells lost with age by introducing young and functionally active fibroblasts into the skin. Fibroblasts are the main cellular component of the skin, providing its homeostasis and morphofunctional organization. They perform a number of diverse and complex functions in the skin: they control the composition and structure of the extracellular matrix of the dermis (collagen, elastin, proteoglycans and structural glycoproteins), and their function includes not only the production of these substances, but also their catabolism. Thus, fibroblasts are a key link in skin biology - they not only control the homeostasis of the extracellular matrix of the dermis, providing for its remodeling and renewal, but also maintain the physiological state of all layers of the skin.


HOW IT WORKS

  • The use of cultured autologous dermal fibroblasts makes up for the lost population of these cells with age.

  • After transplantation, cultured DFs are fully integrated into the dermis

  • The biosynthetic activity of DF is maintained for at least 12 months as a result, there is a remodeling of the microstructure of the dermis, an increase in the content of collagen fibers in it.

  • The hydration of the skin increases, its density and thickness increases as well.


BENEFITS AND THE EFFICIENCY

Active fibroblasts being introduced into the skin , start the natural processes of the dermis restoration The number of dermal cells in the transplantation zone increases, as well as the synthesis of own collagen, microcirculation is restored, metabolic processes and blood circulation are stimulated.

The high efficiency of the method is due to the ability of implanted living own cells for a long time (8-9 months) to produce biologically active substances characteristic of young skin: its strength and elasticity increase, and the lifting effect occurs. The result of implantation of living cells: wrinkles, scars, striae disappear. The dermis is completely renewed, a healthy skin color is restored, its turgor rises, the skin becomes velvety, dryness and peeling disappear. The effect of the procedure begins to manifest itself after 6 - 8 hours after the session and increases over time. After 8 to 9 months after the course of treatment, a persistent positive result is observed. The clinical effect has a growing character throughout the year and persists for at least 3 years

                  CONTACT US:

 Headquarters: 220004, Belarus, Minsk, Nemiga ave. 38 

 +375 25 934-16-18

precision.medical.center@gmail.com 

Sun: Closed, Mon-Fri: 8 am-6 pm, Sat: 10 am-4 pm

Precision Medical Center Minisk Belarus